Icam-1 (cd54): A Counter-receptor For Mac

Posted : admin On 16.05.2019
Icam-1 (cd54): A Counter-receptor For Mac Average ratng: 5,7/10 199 reviews
Icam-1 (cd54): A Counter-receptor For Mac

The functional role of Mac-1 was first illustrated by the ability of anti-Mac-1 α-subunit monoclonal. ICAM-1 (CD54) is a cell surface adhesion receptor that is a member of the. 143(10):3325-3329 (1989); Luscinskas, F.W., et al., J. CD54 mediates important cell-cell interactions and adhesion reactions by binding to its major ligands, LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 may also act as a receptor for rhinoviruses and some coxsackieviruses. CD54 is expressed on lymphocytes, monocytes, macrophages, dendritic cells, endothelial cells, and high endothelial venules.

Both the integrins LFA-1 and Mac-1 bind to ICAM-1, an immunoglobulin superfamily member. Previously, we localized the binding sites of LFA-1 and the major group of human rhinoviruses to the first NH 2-terminal immunoglobulin-like domain of ICAM-1. Here, we show that the binding site on ICAM-1 for Mac-1 is unexpectedly distinct from that for LFA-1 and maps to the third NH 2-terminal immunoglobulin-like domain. These findings provide a function for the tandem duplication of immunoglobulin-like domains in ICAM-1 and have implications for other immunoglobulin superfamily members.

Mutations at two sites in the third domain that destroy consensus sequences for N-linked glycosylation enhance binding to purified Mac-1. Agents that interfere with carbohydrate processing provide evidence that the size of the N-linked oligosaccharide side chains on ICAM-1 affects binding to Mac-1 but not to LFA-1. Thus, we suggest that the extent of glycosylation on ICAM-1 may regulate adhesion to LFA-1 or Mac-1 in vivo. Please enable JavaScript to view the Cell Press Commenting Guidelines To submit a comment for a journal article, please use the space above and note the following:. We will review submitted comments within 2 business days. This forum is intended for constructive dialog.

Icam-1 (cd54) A Counter-receptor For Mac Os X

Comments that are commercial or promotional in nature, pertain to specific medical cases, are not relevant to the article for which they have been submitted, or are otherwise inappropriate will not be posted. We recommend that commenters identify themselves with full names and affiliations. Comments must be in compliance with our. Comments will not be peer-reviewed.